A London teenager Luke Rutherford learns that he is the last descendant of the Van Helsing line by the sudden arrival of his American godfather Rupert Galvin. Luke is charged with the role of smiting the gathering dark forces of the world. At the same time he tries to live an ordinary life of exams and parties. Rupert Galvin helps train Luke with the assistance of Mina Harker, a blind vampiric concert pianist. Luke’s best friend Ruby also joins in on the action.